Levitra (vardenafil) for treatment of ED is rapidly absorbed after oral administration. The drug has bioavailability of about 15%. The max concentration in plasma is reached between half an hour and 2 hours after and oral dose.

The drug is metabolized by CYP3A4 (Cytochrome P₄₅₀ 3A4 one of the most important enzymes involved in the metabolism) and the M1 metabolite has 7% of the total activity.

The drug is eliminated after 4-6 hours, mostly as metabolites in feces (91-95%) and in urine (2-6%).

It is proved by studies that hepatic function impairment when taking this drug is connected with increased plasma levels. So the starting dose for such patients with moderate hepatic impairment should be 5mg, it is also recommended not to exceed the dose more than 10mg.

For men over 65 years the concentration of the drug in plasma and AUC (Area under the Curve) values which determine other pharmacokinetic parameters, such as clearance or bioavailability are increased 34% and 52% in comparison with men 18 to 45 years old.

Generic Name: vardenafil
Brand Name: Levitra

Levitra doses:

-Tablets 2.5 mg
- Tablets 5 mg
- Tablets 10 mg
- Tablets 20 mg

Levitra (active component – Vardenafil Hydrochloride) is indicated for erectile dysfunction treatment, it works by relaxing muscles and increasing blood flow to penis.

Vardenafil Hydrochloride is a phosphodiesterase type 5 (PDE5) inhibitor. It is important to understand that Levitra works by helping to increase blood flow into the penis during sexual stimulation. With the help of the drug you can achieve and maintain an erection.

Vardenafil enhances the effect of nitric oxide at the nerve ending and endothelial cells in the body by inhibiting PDE5 in the corpus cavernosum of the penis. This causes vasodilation –enlarged blood inflow into penis and ensures penile erection by sexual stimulation.

Everyday millions of men worldwide have filled prescriptions for Erectile Dysfunction treatment, making these medications the most successful and useful drugs. Medical science has seemed well on the way to victory over impotence in men in recent decades.  After great success of Viagra, GlaxoSmithKline created Levitra which is similar in profile to Viagra.

For males, the inability to get or sustain an erection usually results in all kinds of performance anxiety and self-esteem problems. There is a variety of factors causing erectile dysfunction – from physical disorders such as heart disease, prostate cancer and diabetes to psychological problems like stress, anxiety and depression.

It is proved that drugs widely prescribed to treat anxiety and depression such as: Paxil, Prozac, Zoloft have sexual side effects. They can make it difficult to achieve an erection or have an orgasm.

Until ED therapies appeared, the typical treatments for impotence were penile implants, penile injections, vacuum pumping and insertion of a suppository into male’s urethra.

These medications for treatment ED have made male’s sexual life better and longer, still they have some side effects – headache, stomach upset, flushing (a warmth and redness of the face, neck and upper chest), nasal congestion and changes in vision. That is why before starting treatment with such medications it is necessary to consult your doctor.